Does Pregabalin Cause Hair Loss?
Pregabalin is a widely prescribed medication primarily used to manage neuropathic pain, seizures, and anxiety disorders. While many patients benefit from its therapeutic effects, concerns about potential side effects often arise. One issue that has gained attention is the possibility of hair loss associated with Pregabalin use.
In this blog, we will explore the relationship between Pregabalin and hair loss, examining scientific research, anecdotal evidence, and potential mechanisms behind this concern. Understanding these connections can help patients make informed decisions about their treatment options. Whether you are currently taking Pregabalin or considering it as a treatment option, this information is crucial for managing your health effectively.
Understanding Pregabalin
Pregabalin is a medication commonly used as an effective pain management option for neuropathic pain, along with epilepsy and generalized anxiety disorder (GAD). It is available under the brand drugs Nervigesic and Lyrica.
Pregabalin is an anticonvulsant drug that works by inhibiting the release of excitatory neurotransmitters, thereby reducing pain perception and stabilizing mood.
The Link Between Pregabalin And Hair Loss
Pregabalin has been associated with hair loss in some patients within 2 to 3 months after starting treatment. In one case, hair loss began just 21 days after initiating pregabalin treatment. This hair loss is thought to result from the medication causing hair to stop growing earlier than it should [1].
Hair growth goes through different stages, and when it reaches the last or the resting stage too quickly, more hair falls out than normal. This condition is known as telogen effluvium, resulting in increased hair shedding [1].
The prescribing information for Pregabalin (Lyrica) by its manufacturer lists alopecia (hair loss) as an infrequent side effect, suggesting it is not a common side effect and affects about 0.01% of its users [2].
Factors Influencing Hair Loss
Hair loss due to Pregabalin can be exacerbated by a previously unknown underlying genetic tendency or the presence of one or more other hair loss risk factors [3]. It is crucial to rule out other potential causes of hair loss, such as thyroid disorders, stress, and nutritional deficiencies, before attributing hair loss to Pregabalin.
Some of the factors that influence hair loss include-
Nutritional Deficiencies
Nutritional deficiencies, particularly those of protein, vitamins, and iron, can lead to hair loss. A study conducted by Emily L. Guo and Rajani Katta indicates that inadequate nutrition may impact both hair structure and growth [4]. The key nutrients identified in this study, whose deficiencies can contribute to hair loss, include:
- Zinc
- Niacin (Vitamin B3)
- Selenium
- Vitamin D
- Vitamin A
- Vitamin E
- Folic Acid
- Biotin
Addressing these nutritional gaps is essential for maintaining healthy hair.
Thyroid disease
Hair loss can be a significant symptom of severe and prolonged thyroid disorders. Unlike other types of hair loss, this condition typically results in diffuse thinning across the entire scalp rather than isolated patches. Fortunately, hair regrowth is generally possible following effective treatment [5].
Pregnancy
Experiencing hair loss after childbirth is very common. This is due to a decrease in the estrogen level. Hair loss during pregnancy affects between 40 to 50% of women [6].
Genetics
Hereditary-pattern baldness is one of the leading causes of hair loss, as highlighted by research from Harvard. This condition typically arises from a combination of genetic factors, hormonal changes, and the natural aging process. Notably, up to 40% of both men and women are affected by hereditary hair loss [7].
Is Hair Loss From Pregabalin Permanent?
Hair loss from Pregabalin is generally not permanent. While some individuals may experience this side effects of pregabalin, it typically resolves after discontinuing the medication.
In a case study by Celalletin Turgut and Alparslan Ali, hair loss stopped entirely within 15 days of discontinuing Pregabalin, highlighting its potentially reversible nature [1].
It is important to note that individual reactions can vary, so it is important to consult with a doctor.
Managing Hair Loss Caused By Pregabalin
Managing hair loss caused by Pregabalin can be improved in the following ways-
Diet And Supplements
Several studies indicate that vitamin and mineral supplements can improve symptoms of hair loss as they are important for normal cell growth and functioning [8].
Some deficiencies that are associated with hair loss include-
- vitamin D
- iron
- vitamin C
Taking a balanced diet and having additional health suppelemts can help with managing hair loss.
Minoxidil Topical Solution
Minoxidil is a treatment used to help with hair loss. It is applied directly to the scalp and works by improving blood flow to hair follicles, promoting hair growth.
It was originally developed as a medication for high blood pressure and works by widening blood vessels, which increases blood flow to hair follicles, potentially stimulating hair growth [9].
Available in topical forms such as a liquid solution or foam, it typically comes in 2% and 5% concentrations. For best results, it is recommended to apply it directly to the scalp twice a day on clean, dry hair.
Pumpkin Seed Oil
Pumpkin seed oil has gained attention as a natural remedy for hair growth, particularly due to its potential to reduce the effects of 5-alpha reductase. This enzyme is known to contribute to hair loss by converting testosterone into dihydrotestosterone (DHT), which can lead to hair thinning [8].
A 2019 study conducted on mice suggests that the fatty acids found in pumpkin seed oil may promote hair growth when applied topically. This finding points to pumpkin seed oil as a promising alternative for people looking to treat hair loss naturally [10].
Head Massage
Some studies suggest that regular head massages might help make hair grow thicker. Head massages are known to reduce stress, which can contribute to hair loss.
A study by Taro Koyama et al. found that scalp massage can apply gentle pressure to the skin on the head, which might help improve hair thickness [11].
To give yourself a scalp massage, you can use a head message tool or simply use your fingers to gently press, stretch, and pinch your scalp for a few minutes each day.
Can Pregabalin Cause Hair Loss- Our Final Thoughts
Pregabalin has been associated with various side effects, though hair loss is not commonly listed among them. However, some individuals have reported experiencing hair loss while taking the medication. It is important to recognize that side effects can vary significantly from person to person.
Additionally, hair loss can stem from multiple factors, including stress, hormonal changes, nutritional deficiencies, or genetics.
FAQs
Does Lyrica cause hair loss?
How often does Lyrica cause hair loss?
How long does Pregabalin take to cause hair loss?
References
- Hair loss due to Pregabalin: a case report, dergipark.
- Lyrica- Pregabalin capsule, Pfizer.
- Does Gabapentin Make Your Hair Fall Out?, baumanmedical.
- Diet and hair loss: effects of nutrient deficiency and supplement use, NCBI.
- Hair loss and thyroid disorders, btf-thyroid.org.
- Hair Loss During Pregnancy: Telogen Effluvium, americanpregnancy.org.
- Hereditary-patterned baldness, health.harvard.edu.
- How to treat hair loss from medication, medicalnewstoday.
- Minoxidil, wikipedia.
- Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model, NCBI.
- Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue, NCBI.
