The Risks Of Combining Pregabalin (Lyrica) And Tramadol: What You Need To Know

When managing chronic pain, many individuals rely on prescription medications to help alleviate discomfort and improve their quality of life. Pregabalin (Lyrica) and Tramadol are two commonly prescribed drugs used to treat conditions like nerve pain, fibromyalgia, and other chronic pain disorders. However, while these medications can be effective on their own, combining them can lead to serious health risks that should not be overlooked.

In this blog, we will explore the potential dangers of using Pregabalin and Tramadol together, how they work, and the precautions you should take to ensure your safety while managing your pain.

Understanding Pregabalin (Lyrica) And Tramadol

Pregabalin is an anticonvulsant drug that is used to treat epilepsy, fibromyalgia, neuropathic pain, and generalized anxiety disorder (GAD) [1]. In some cases, it is used as an add-on therapy for partial seizures. Pregabalin is available under numerous brands of drugs, such as Lyrica and Nervigesic. Its medical use was approved in the USA in 2004 and was developed as a successor to Gabapentin [1].

Lyrica is available in generic options such as Nervigesic. Manufactured by Signature Pharmaceuticals Ltd in India, it is similar to the brand medication when it comes to its effectiveness and safety profile. The Nervigesic medication is available in numerous dosage strengths, where lower doses, like Nervigesic 75 mg, are recommended for beginners with mild body pain.

Tramadol, also sold under the brand name Ultram, is an opioid pain medication that is prescribed for treating moderate to severe pain [2]. Tramadol was patented in 1972 and was launched under the name Tramal in 1977 by a pharmaceutical company called Grünenthal GmbH.

The Dangers Of Combining Pregabalin And Tramadol

When taking medications that act on the central nervous system (CNS), such as Pregabalin (Lyrica) and Tramadol, it is essential to be aware of potential risks, especially when used together. Both of these drugs can affect CNS activity, and combining them can increase the likelihood of serious side effects.

Some of the risks of combining Pregabalin and Tramadol are-

Respiratory Depression

One of the most severe risks of combining Pregabalin with narcotic pain medications like Tramadol is respiratory depression, which can be fatal. Respiratory depression occurs when breathing becomes too slow or shallow, and in extreme cases, it can lead to respiratory failure [3].

Impaired Judgment And Coordination

Both Pregabalin and Tramadol can cause drowsiness, dizziness, and difficulty concentrating. Together, these medications may impair judgment, slow reaction times, and reduce motor coordination [3]. This makes activities such as driving or operating heavy machinery hazardous.

Coma And Overdose

In severe cases, CNS depression caused by the combined use of these drugs can result in a coma. The risk of overdose and death increases if the doses are not carefully managed, particularly in individuals with certain pre-existing conditions.

While the combination of these medications can be risky, there are certain situations in which it might be appropriate for some patients. For instance, individuals who suffer from both nerve pain, such as diabetic neuropathy, and pain from cancer may be prescribed Pregabalin for nerve pain and Tramadol for cancer-related pain.

According to Dr. Aaron Gilbert, Pharm.D., a pharmacy manager at HealthWarehouse.com, “taking both is generally okay for most people, but not always.” [4]

The website Drugs also suggests a severe drug interaction when Lyrica and Tramadol are taken together. Thus, these medications should only be taken together after consulting a doctor.

Special Considerations While taking Tramadol and Pregabalin

Some of the key considerations while taking Tramadol and Pregabalin include-

Elderly patients

Older individuals, particularly those over 65, are at higher risk for side effects due to their slower metabolism and increased sensitivity to medications. If you fall into this category, your doctor may start you on a lower dose or monitor you more closely for side effects [4].

Patients with Respiratory Conditions

People with lung diseases like asthma, chronic obstructive pulmonary disease (COPD), or other respiratory conditions should avoid this combination altogether [5].

Precautions and Tips for Safe Use Of Tramadol And Lyrica

If your doctor prescribes both Pregabalin and Tramadol, there are several important guidelines to follow to minimize the risk of severe side effects.

Avoid Alcohol

Both Pregabalin and Tramadol affect the CNS, and alcohol can intensify these effects. Drinking alcohol while taking these medications can increase sedation, confusion, and dizziness and even lead to more severe respiratory problems [4].

Monitor For Pregabalin And Tramadol Side Effects

Be aware of how your body responds when you start taking both medications. If you experience extreme drowsiness, dizziness, or difficulty breathing, seek medical attention immediately [6].

Inform Your Doctor About All Medications

Always tell your doctor about all the medications, including vitamins and herbal supplements, that you are currently taking. This ensures that potential interactions are properly managed [6].

Side Effects Of Taking Tramadol And Lyrica Together

The risks of taking Tramadol and Lyrica (Pregabalin) together include-

• Dizziness
• Drowsiness
• Headaches
• Palpitation
• Allergic reactions such as rashes, hives, and itching.
• Sedation.

Safer Alternatives And Pain Management Options

When managing pain, particularly in cases where traditional medications like Tramadol and Pregabalin may not be suitable or effective, it is important to explore other safer alternatives. Two potent and effective options that can offer relief include Carisoprodol and Tapentadol, both of which serve specific roles in pain management.

Carisoprodol (Soma)-

Carisoprodol is a skeletal muscle relaxant commonly used to treat acute musculoskeletal pain and spasms. The use of the Soma pill is effective in managing pain related to muscle strains, sprains, and spasms. Beginners are recommended to start with a lower dosage, such as Soma Dol 350mg. Another effective option for people looking to start with Carisoprodol treatment is Pain O Soma 350mg.

Tapentadol

For more severe and chronic pain, Tapentadol is an alternative worth considering. It is a centrally acting analgesic, combining the mechanisms of both opioid and non-opioid pain relief. Tapentadol is effective for managing moderate to severe pain associated with neuropathic pain and osteoarthritis. Effective Tapentadol options available in the market include Aspadol, Topcynta, and Tapaday. Being an opioid pain medicine, it is recommended to start with a lower dosage, such as Tapaday 100 mg, to avoid overdose or dependency.

Can You Take Tramadol With Pregabalin- Our Final Thought

The Pregabalin or Lyrica and Tramadol interaction can pose significant risks due to their combined effects on the central nervous system (CNS). While these medications are both effective for managing pain, using them together can lead to serious complications, including respiratory depression, impaired judgment and coordination, and, in extreme cases, coma or even death.

The CNS-depressant properties of both drugs can significantly amplify each other’s sedative effects, leading to dangerous outcomes, particularly in higher doses or when taken together simultaneously.

While some studies suggest that healthy individuals may tolerate the combination, those with pre-existing conditions, such as respiratory disorders or individuals over the age of 65, should be cautious. For such people, the risk of severe side effects is heightened, and careful monitoring is essential.

Ultimately, Pregabalin and Tramadol can be effective pain management options when used appropriately. Following medical guidance and staying cautious of any signs of dangerous side effects is important.